At least three people were killed and 15 others were injured Tuesday after a crash on an Ohio interstate between a semi-trailer and a bus carrying students.

Shortly after 9 a.m., the semi rear-ended the bus on Interstate 70 West in Licking County, The Associated Press reported.

The charter bus was transporting students from a school in eastern Ohio, said Licking County Emergency Management Agency Director Sean Grady, who confirmed the death toll and injury toll in an interview with NBC News.

A total of 57 people were on board, he said.

The injured were taken to area hospitals with injuries. Their conditions and the cause of the accident were not immediately clear.

This is a developing story. Please check for updates.